Neutropenia (granulocytopenia, agranulocytosis) - reduction of blood neutrophils, often increases susceptibility to bacterial and fungal infections.
On the number of neutrophils in the blood (the total number of leukocytes, multiplied by the percentage of neutrophils) and, accordingly, the risk of infection distinguish light (1000 - 2000 of neutrophils in 1 mm), medium (500 - 1000/mkl) and severe neutropenia (less than 500/mkl) . Severe acute neutropenia caused by a violation of Education of neutrophils, often poses a risk to life.
Reasons. Neutropenia is due to a breach of education neutrophils, regional state of neutrophils (congestion at the walls of blood vessels) with redistribution of blood, their rapid recovery and reduce the lifetime. The condition may be acute (developing over several days) or chronic (lasts months or years). Sometimes this is an isolated anomaly, but in other cases - a manifestation of hematologic (blood-related) diseases.
The most common cause of neutropenia - neutrophil brand name viagra depression education drugs (such as cytotoxic antitumor agents, anticonvulsants, sulfonamides, etc.). Neutropenia refers to an inevitable side effect of some antitumor drugs (eg alkylating agents, antimetabolites). Other drugs cause neutropenia as an idiosyncratic reaction (does not depend on the dosage or duration of the medication).
The decrease of neutrophil production is also observed in some rare hereditary and congenital anomalies (eg, hereditary agranulocytosis in children during the first months of life, with family neutropenia, cyclic neutropenia, in some diseases in which the violation production of neutrophils combined with a severe immunodeficiency). Sometimes the formation of neutrophils disrupted due to a bone marrow transplant or destruction (eg, cancer and granulomatous disease) as well as the usual manifestation of severe deficiency of vitamin B12 and folic acid.
Manifestations. Neutropenia has no specific manifestations, except for those associated with the proceeding against it and the infection Viagra an epidemic usually depends on the severity, duration and causes of neutropenia. In acute neutropenia fever are not uncommon, the appearance of painful ulcers on the mucous membrane of mouth and anus, the development of bacterial pneumonia. If you do not start treatment in the future there develops bacteremia and septic shock. Chronic neutropenia is often far more benign, especially if it is a mild or moderate form, the number of monocytes in the blood normally, and the functions of other immune system components (eg immunoglobulins, complement and lymphocytes) are not changed.
Treatment by a doctor. Gargle every few hours with saline or hydrogen peroxide, pain relievers, lozenges (benzocaine, 15 mg every 3 - 4 h) or rinse the mouth of 1% chlorhexidine ease discomfort associated with ulceration.
Chronic neutropenia - a tactic should be expectant: patients should be warned that he should immediately seek medical attention when the temperature rises and other signs of infection.
Something interesting
Neutropenia (agranulocytosis) occurs (as a side effect), using very high doses of captopril (hood) of patients with connective tissue and impaired renal function after 3 - 6 months of treatment. Typically, the number of leukocytes recovered within three months after the abolition of drugs.
Excellent results
University of Minnesota
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